Acyclovir (Injection)

Acyclovir (Injection) is an antiviral medication indicated for the treatment of various severe viral infections caused by herpesviruses, including Herpes Simplex Virus (HSV) and Varicella Zoster Virus (VZV), particularly in immunocompromised or hospitalized patients. It is administered intravenously in clinical settings where oral therapy is inappropriate or insufficient.

✅ Approved & Common Indications

🌿 Herpes Simplex Virus (HSV) Infections

• Herpes Simplex Encephalitis:
  Treatment of life-threatening HSV encephalitis in both immunocompetent and immunocompromised patients.
• Neonatal Herpes Simplex Infections:
  For the management of disseminated, central nervous system (CNS), or localized neonatal HSV infections.
• Severe Mucocutaneous HSV Infections:
  For severe initial or recurrent mucocutaneous herpes infections in immunocompromised patients, including those with HIV/AIDS, malignancy, or undergoing chemotherapy.

🌿 Varicella Zoster Virus (VZV) Infections

• Herpes Zoster (Shingles):
  Treatment of disseminated or severe herpes zoster infections in immunocompromised individuals or hospitalized patients.
• Varicella (Chickenpox):
  Management of serious varicella infections in immunocompromised patients when oral antivirals are not feasible.

🌿 Prophylaxis of Herpesvirus Infections in Immunocompromised Patients

• For the prevention of HSV and VZV reactivation in immunocompromised patients (e.g., bone marrow transplant recipients, organ transplant recipients, patients receiving intensive chemotherapy).

📌 Off-Label & Investigational Uses

• Occasionally used as adjunctive therapy in immunocompromised patients with Epstein-Barr Virus (EBV)-associated diseases or severe cytomegalovirus (CMV) infections, though not FDA-approved for these indications.