Alendronic Acid + Vitamin D3

Alendronic Acid + Vitamin D3 is a fixed-dose combination medication used for the treatment of bone disorders characterized by decreased bone mass and strength. Alendronic Acid, a bisphosphonate, inhibits osteoclast-mediated bone resorption, while Vitamin D3 (cholecalciferol) enhances calcium absorption and helps maintain optimal serum calcium and phosphate levels for healthy bone mineralization.

✅ Approved & Common Indications

🌿 Osteoporosis in Postmenopausal Women

• Indicated for the treatment of osteoporosis in postmenopausal women to reduce the risk of vertebral and hip fractures.
• Vitamin D3 supplementation helps correct or prevent concurrent vitamin D deficiency, essential for optimal bone health and effective action of bisphosphonates.

🌿 Osteoporosis in Men

• Indicated for the treatment of osteoporosis in men at increased risk of fractures, including those with risk factors such as low bone mineral density (BMD) or prior osteoporotic fractures.

🌿 Glucocorticoid-Induced Osteoporosis (GIOP)

• Indicated for the prevention and treatment of osteoporosis in patients receiving long-term systemic glucocorticoids.
• Prevents rapid bone loss associated with steroid use, while Vitamin D3 supports calcium metabolism and reduces the risk of secondary hyperparathyroidism.

🌿 Vitamin D Deficiency in Osteoporotic Patients

• Indicated for the simultaneous management of osteoporosis and prevention or correction of vitamin D deficiency or insufficiency in adults, ensuring adequate levels for effective calcium absorption and bone strength.

🌿 Other Potential Uses (Off-label / Supportive Therapy)

This combination has also been utilized in:

• Osteopenia with suboptimal vitamin D levels to help prevent progression to osteoporosis.
• Prevention of bone loss in patients undergoing androgen deprivation therapy (ADT) for prostate cancer or aromatase inhibitor therapy for breast cancer, especially in individuals at risk of vitamin D deficiency.
• Secondary osteoporosis due to other medical conditions associated with low BMD and vitamin D insufficiency.