Amino Acid Ketoanalogues

Amino Acid Ketoanalogues are nitrogen-free analogues of essential amino acids, used as nutritional therapy in patients with chronic kidney disease (CKD). These compounds help reduce nitrogen load, slow the progression of kidney dysfunction, and correct protein malnutrition while minimizing uremic toxin buildup.

✅ Approved & Common Indications

🌿 Chronic Kidney Disease (CKD) – Stages 3 to 5 (Pre-Dialysis)

• Indicated as a supplement to a low-protein diet in patients with CKD to: 📌 Reduce nitrogenous waste accumulation
  📌 Delay the progression of renal failure
  📌 Improve metabolic parameters (e.g., acidosis, hyperphosphatemia)
  📌 Maintain adequate nutritional status

🌿 Protein-Energy Wasting (PEW) in Renal Disease

• Supports muscle mass maintenance and prevents malnutrition in CKD patients who are on protein-restricted diets.

🌿 Uremic Symptoms Control

• May help reduce uremic symptoms in advanced CKD patients not yet on dialysis.

🌿 Renal Replacement Therapy Delay

• Shown in some studies to help postpone the initiation of dialysis when used with a strict protein-restricted diet.