Anti-human T-lymphocyte Immunoglobulin

Anti-human T-lymphocyte Immunoglobulin is a purified polyclonal immunoglobulin derived from animals (usually rabbits or horses) immunized with human T-cells. It exerts potent immunosuppressive effects by depleting functional T-lymphocytes and modulating immune activity. This biologic agent is primarily used in transplant medicine and hematological conditions where immune suppression is critical.

✅ Approved & Common Indications

🌿 Prevention and Treatment of Acute Rejection in Organ Transplantation

• Indicated for the prevention and management of acute rejection episodes in patients undergoing kidney, heart, or liver transplantation.
• Commonly used as part of induction immunosuppressive therapy or in cases of steroid-resistant rejection.

🌿 Severe Aplastic Anemia (SAA)

• Indicated in the immunosuppressive treatment of severe aplastic anemia, especially in patients ineligible for hematopoietic stem cell transplantation (HSCT).
• Administered in combination with agents such as cyclosporine to promote hematologic recovery.

🌿 Hematopoietic Stem Cell Transplantation (HSCT)

• Used in conditioning regimens prior to allogeneic HSCT to reduce the risk of graft rejection and prevent graft-versus-host disease (GVHD).
• Often employed in mismatched or unrelated donor transplants where immune modulation is essential.

🌿 Other Off-label/Supportive Uses (Specialist-Guided)

• Treatment of hemophagocytic lymphohistiocytosis (HLH)
• Chronic graft-versus-host disease (cGVHD) management
• Refractory autoimmune diseases, such as systemic lupus erythematosus (SLE) or myasthenia gravis (in rare, severe cases)